Sissy Blakley is Johnny's on/off antagonist.
Sissy is a 11-year-old girl who is a rival of Johnny who's older than her, and she is much smarter than him. Johnny also seems to have a crush on her, but he doesn't hide it as well as her, although he doesn't show it because he mocks her and makes fun of her (e.g., when Johnny refused Dukey's claim that he actually likes Sissy by announcing that he hates Sissy, Dukey told him, "At your age, Johnny, it's the same thing"). However, the two are constantly competing against each other. If Sissy beats him, she will brag about it. If Johnny wins, he'll either get caught into a situation because of it, or brag as much as her. In one episode, Johnny pretends to get used to being bullied by Sissy and they fall in love with each other along with Dukey and Missy. She seems to be the victim to the show's twists, adventures, and misadventures at the end of the episodes that she appears in. She appears in the first and second season, but made a brief cameo in the background during an episode in Season Three, and several appearances in season 4 with a few in 5. She has blonde hair with a red lightning bolt pattern, multiple ear piercings & white sashes on her skirt with pants underneath. Sissy may actually like Johnny, because in Princess Johnny , she was paying him to play princess with her, and in The Good, the Bad & the Johnny , after Johnny gives flowers to her, she kisses him, and in Johnny Irresistible it shows that Sissy likes him because she says "I wanna kiss him, and kiss him, and kiss him!" She also appears to like him in Johnny B.C because Sissy "in love" is a sign the sisters and Dukey use to find Johnny after Johnny (who was still aa caveman) licks Sissy.
Sissy has waist long blond hair held back in a pony tail with bangs curled up and a red lightning bolt shaped streak. she has multiple ear piercings, has fair skin and large blue eyes with extremely long black eyelashes. Her normal attire consists of a black t-shirt with a blue camisole under with a red plaid skirt over jeans with two crisscrossed white belts and black and white checker board print sneakers and a red plaid head band, a black choker and pink lipstick. Her eyebrows are very thin and maybe drawn on.
She has worn a ladybird scout uniform consisting of a green skirt, a green polo shirt with a pink bolo tie, a green beriet dress with a pink upside down triangle with an acorn in the middle. She also sports a badge sash across that has a large amount of badges on it.
When Johnny and Dukey get shrunk down to more then micoscopic size and are sent to a alternite universe, the Sissy there appears the same but her hair is red and the lightning bolt is blond.
Johnny is the only one she likes in the series and Johnny sort of kind of likes her too. In almost every episode where Sissy appears it has been hinted that she likes him (ex.Saturday Night's Alright for Johnny, and Johnny's 100th Episode). Sissy tends to hide her crush very well through bullying him and asserting superiority over him.
- "You didn't write a play about garbage, THIS IS GARBAGE!" - Good Ol' Johnny Test
- "We DIE???" - Good Ol' Johnny Test
- "Hey, I'm paying you, remember???" - Princess Johnny
- "I'm William, and I'm TELLING you...you're the apple." - Saturday Night's Alright for Johnny
- How can you not love a show about a kid who's older brothers do experiments on him?"- Johnny Re-Animated
- Does that mean you like me!?-Johnny B.C
- That's it! I'll take the F! - Who's Johnny? Playing Two Johnny Dodgeball
- She is known as the Speedster in her school.
- Janet Nelson Junior was intended to take the role of Sissy, but was phased out and was replaced with Sissy for unknown reasons until the fifth season.
- Her name might be a pun on the fact that Johnny thinks girls are sissies.
- Sissy is the first girl to kiss Johnny and the only time that he thinks it's gross.
- She first appeared in Johnny Impossible.
- Her name is ironic because she is not a sissy.